What is Kisspeptin-10?
It is the ten-residue C-terminal active fragment of kisspeptin used as a KISS1R research ligand.
Research materialResearch use only
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Technical Specifications
A ten-amino-acid active kisspeptin fragment and KISS1R ligand; it is intentionally cross-listed in metabolic and neuropeptide research categories.
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Research material
Kisspeptin-10
Kisspeptin-10 is the C-terminal decapeptide of kisspeptin, encoded by the KISS1 gene and recognized as an active ligand for the kisspeptin receptor, KISS1R. It is widely used in neuroendocrine research because kisspeptin signalling is positioned upstream of gonadotropin-releasing hormone networks. The short active fragment provides a defined molecular probe for receptor pharmacology, ligand–receptor interaction studies, and hypothalamic signalling models. Its relevance spans both metabolic-endocrine and neuropeptide-receptor research, reflecting the integration of reproductive, energy-status, and central signalling systems. This content is educational and is limited to research context.
Research highlights
- KISS1R receptor pharmacology; neuroendocrine signalling; hypothalamic networks; reproductive-axis research; energy-status and endocrine integration.
- Kisspeptin research includes molecular, cellular, animal, and human physiological investigation. This material is described for research use only.
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$89.99
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10 mgCurrently sold out — available for pre-order
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Technical Specifications
A ten-amino-acid active kisspeptin fragment and KISS1R ligand; it is intentionally cross-listed in metabolic and neuropeptide research categories.
Research use only
Materials are intended strictly for laboratory and analytical research.
Contact research supportMechanism & Research Pathways
Kisspeptin-10 activates KISS1R, a Gq/11-coupled receptor commonly associated with phospholipase C, intracellular calcium mobilization, and MAPK-related signalling in experimental systems. In hypothalamic models, kisspeptin signalling is studied for its relationship to GnRH neuronal activity and broader neuroendocrine coordination. Receptor expression, ligand exposure, species, and experimental preparation can shape observed responses. Research often distinguishes direct receptor pharmacology from higher-order endocrine effects measured in whole-animal or clinical settings; those levels of evidence should not be treated as interchangeable.
Research Context
Kisspeptin research includes molecular, cellular, animal, and human physiological investigation. This material is described for research use only.
Frequently Asked Research Questions
What receptor does Kisspeptin-10 activate?
Its primary established target is the kisspeptin receptor KISS1R.
Why is it cross-listed?
Kisspeptin signalling links neuropeptide receptor biology with broader neuroendocrine and metabolic research questions.